Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.
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چکیده
منابع مشابه
Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor
To investigate the question of whether lytic granules share a common biogenesis with lysosomes, cloned cytolytic T cell lines were derived from a patient with I-cell disease. The targeting of two soluble lytic granule components, granzymes A and B, was studied in these cells which lack a functional mannose-6-phosphate (Man-6-P) receptor-mediated pathway to lysosomes. Using antibodies and enzyma...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1993
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.120.4.885